Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-PNP Size:50mg 12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment:

12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment: 98 atom % D Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

542 Purity (HPLC) >= 95% Solubility DMSO

NCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

van Montfort

79 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-PNP Size:50mg 12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment:SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine