Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:25mg 69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC)

69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Protein degrader building block

389 SMILES CC(C)(C)OC(=O)N1CCN(CC1)C1CCNCC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name 2-chloro-1-(methoxy-d3)-4-nitrobenzene Synonyms CAS Number n/a Related CAS Molecular Formula C7H6ClNO3 Molecular Weight 190

Product Name CP- diAcFAM Synonyms SNAP2- diAcFAM CAS Number Related CAS Molecular Formula C37H27ClN4O9 Molecular Weight 707

Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:25mg 69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous