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89 SMILES ClCCOCCOCCOCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name NRX-103095 Synonyms CAS Number 2763260-38-2 Related CAS Molecular Formula C22H16Cl2F3N3O3S Molecular Weight 530
NCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C45H59N11O14 Molecular Weight 978
041 Purity (HPLC) >= 95% Solubility DMSO
Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan macrophage 89 SMILES ClCCOCCOCCOCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU
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