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It reacts with thiol compounds such as amino acid
It binds to the VHL E3 ligase with an IC50 of 0
925 Purity (HPLC) >= 95% Solubility DMSO
Product Name Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C68H91FN10O20 Molecular Weight 1387
297 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(NCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
OSu-Glu-VC-PAB-MMAE Size:1mg It reacts with thiol compoundsSuO Glu Val Cit PAB MMAE (NHS Glutarate Val Cit PAB MMAE) is a cleavable ADC linkerpayload system consisting of a SuO Glu Val Cit PAB peptide linker and the microtubule disrupting cytotoxic payload MMAE. This ADC building block is widely used in the synthesis of antibody drug conjugates for cancer research, where the Val Cit PAB motif enables enzyme cleavable release of MMAE inside target cells, supporting highly potent, targeted delivery in
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