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MC-Val-Ala-PAB(m-PEG8)-Exatecan ca S)-AHPC-CO-C2-acid Synonyms CAS Number 2172819-72-4

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Description

S)-AHPC-CO-C2-acid Synonyms CAS Number  2172819-72-4 Related CAS Molecular Formula C26H34N4O6S Molecular Weight 530

Product Name Thalidomide-O-PEG5-C2-Cl Synonyms Thalidomide-4'-O-PEG5-C2-Cl CAS Number n/a Related CAS Molecular Formula C25H33ClN2O10 Molecular Weight 556

Product Name Phthalimidinoglutarimide-propargyl-O-PEG1-C2-amine HCl Synonyms Phthalimidinoglutarimide-4'-propargyl-O-PEG1-C2-amine HCl CAS Number 2138440-68-1 Related CAS Molecular Formula C20H24ClN3O5 Molecular Weight 421

BC-PhN3 is a CLIP-tag substrate containg a phenylazide group for click chemistry applicatoions

Product Name Thalidomide-O-acetamido-C5-acid Synonyms Thalidomide-4'-O-acetamido-C5-acid CAS Number 2354352-06-8 Related CAS Molecular Formula C21H23N3O8 Molecular Weight 445

MC-Val-Ala-PAB(m-PEG8)-Exatecan ca S)-AHPC-CO-C2-acid Synonyms CAS Number 2172819-72-4SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,

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