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SiR-NHS is the NHS ester of SiR-6-COOH (652Ex/674Em) and can be conjugated to amine-containing molecules easily
Product Name DBCO-Propionyl-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C95H141N11O23 Molecular Weight 1805
Product Name Pomalidomide-CO-C3-alkyne Synonyms Pomalidomide-4'-CO-C3-alkyne CAS Number n/a Related CAS Molecular Formula C19H17N3O5 Molecular Weight 367
378 SMILES C[C@H](NC1=CC=C2C3=NC(=CN3CCOC2=C1)N1[C@@H](COC1=O)C(F)F)C(N)=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO
1038/s41467-023-44237-4
Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg SiR-NHS is the NHS esterSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
