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Product Name Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C52H75N9O19 Molecular Weight 1130
Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C96H159N13O29 Molecular Weight 1959
Product Name Thalidomide-O-C5-OH Synonyms Thalidomide-4'-O-C5-OH CAS Number 2411099-10-8 Related CAS Molecular Formula C18H20N2O6 Molecular Weight 360
Massarotti
Compared to earlier iterations
Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan Thalidomide Product Name Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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