Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan AHPC CA-N3 is a HaloTag ligand

CA-N3 is a HaloTag ligand containing an azide functional group

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

COA           MSDS

CA-DOTA-tris(t-Bu) can be used to attach DOTA moiety to protein

It forms a covalent bond with the CLIP-tag protein

Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan AHPC CA-N3 is a HaloTag ligandSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent