Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Size:1mg MaP555 mainly exists in the

MaP555 mainly exists in the fluorescent zwitterion form

Product Name tert-butyl N-{2-[4-(3-aminopropyl)piperazin-1-yl]ethyl}carbamate Synonyms CAS Number 2719062-98-1 Related CAS Molecular Formula C14H30N4O2 Molecular Weight 286

37 SMILES: [H][C@]12CS[C@@H](CCCCC(=O)NCC#C)[C@@]1([H])NC(=O)N2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

167 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C(O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-C6-amine Synonyms CAS Number n/a Related CAS Molecular Formula C22H42N6O7 Molecular Weight 502

Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Size:1mg MaP555 mainly exists in theSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent